Dr. Curt Connors/The Lizard is the main antagonist of The Amazing Spider-Man, where he is played by Rhys Ifans. In this version, Dr. Connors is a biologist for Oscorp and a former partner of Richard Parker where they worked on combining desirable physical attributes of animals with humans to improve health, including restoring his own amputated right arm. Richard's son Peter starts a friendship with him after the boy finds his father's notes that contain a critical equation to make a critical breakthrough. When the representative of Norman Osborn named Dr. Rajit Ratha fires Connors after he refuses to rush into human trials, Connors experiments on himself and finds he has regenerated his arm. Learning that Dr. Ratha is on his way to the VA hospital, Connors goes to intercept him, but it quickly becomes apparent that his "cure" is doing more than was intended as his skin grows scaly and claws sprout from his fingers. By the time he gets to the traffic-jammed Williamsburg Bridge, Connors has transformed into a superhumanly strong humanoid lizard where he tossed some cars (including Dr. Ratha's car) over the side. Spider-Man saves each fallen car with the biocable "web" that he fires from devices he built on his wrists. The Lizard escapes into the sewers and transforms back into Connors, but it's clear that the chemicals have affected his mind, creating an obsession with his new abilities and seeing it as "perfection". He continues to further experiment on himself in an makeshift lab. Spider-Man, who has come to suspect Connors as being the creature who attacked the bridge, confronts the Lizard in the sewers, barely escaping alive, and Lizard learns Spider-Man's real identity and attacks him at school, though the Lizard was forced to escape after the police arrive. The Lizard then develops a plan to make all humans lizard-like, starting with the release of a chemical cloud from Oscorp's tower. The police hunt both Spider-Man and the Lizard. Spider-Man eventually disperses an antidote cloud restoring Connors and his victims to normal, but not before Lizard mortally wounds Captain George Stacy. With the chemicals now cleared, Connors, having gained back his sanity, then proceeds to save Spider-Man from falling from a building using what's left of his quickly dissipating lizard strength. Afterwards, he surrenders himself to the authorities and is arrested for his crimes. In a scene during the end credits, Connors (who has been placed in Beloit Psychiatric Hospital) appears to speak with a mysterious man who asks if Connors told Peter the truth about his father. Connors replies that he didn't, but upon still caring for him, Connors angrily demands the man to leave Peter alone. The man then mysteriously vanishes. It is also hinted that he may still have some form of the serum in his system.